Successful treatment of rapidly progressive interstitial lung disease complicated by a refractory pneumomediastinum in a patient with anti‐MDA5 antibody‐positive dermatomyositis
نویسندگان
چکیده
Introduction Anti-melanoma differentiation-associated gene 5-positive dermatomyositis (anti-MDA5+ DM) is a distinct subtype of DM, which characterized by typical cutaneous features, minimal or no muscle involvement and notable interstitial lung disease, typically progresses rapidly has high mortality. Spontaneous pneumomediastinum (PNM), relatively unusual but serious complication anti-MDA5+ further increases Currently, there generally accepted treatment regimen for DM-associated PNM. Case Description A 53-year-old man with DM presented progressive disease that progressed to diffuse subcutaneous emphysema PNM despite aggressive immunosuppressive therapies. He responded well combined anti-infection treatments, moderate immunotherapy, continuous oxygen therapy. Conclusion Comprehensive screening potential infections, as close monitoring the patient's immune status essential individualizing maximizing prognosis.
منابع مشابه
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ژورنال
عنوان ژورنال: Rheumatology & autoimmunity
سال: 2023
ISSN: ['2767-1429', '2767-1410']
DOI: https://doi.org/10.1002/rai2.12079